Prof. Wolf-Dietrich Hardt - ETH, Zürich
Field of research
The research in Wolf-Dietrich Hardt’s group is focused on the molecular mechanisms of infectious diseases. This includes the evolution and adaptation of pathogens to new hosts and the molecular function of specific bacterial virulence factors. Currently, his lab has a strong focus on Salmonella Typhimurium pathogenesis and how these bacteria employ Type III secretion systems to cause disease.
Specific Contribution to Research in InfectX
The group will perform genome-wide RNAi screens to identify human proteins involved in bacterial entry of Salmonella (“trigger” uptake mechanism).
Lab Members Involved in InfectX
Dr. Mikael Erik Sellin, Postdoctoral Researcher.
Daniel Andritschke, Ph.D. Student
Saskia Kreibich, Ph.D. Student Saskia performs genome-wide RNAi screens to identify host cell factors required for S. Typhimurium host cell invasion
Romina Sigrist, Ph.D. Student
Pascale Vonäsch, Ph.D. Student. Pascale analyzes the biological function of hits identified in the RNAi screens.