Prof. Lucas Pelkmans, Institute of Molecular Life Sciences, University of Zürich
Field of research
Research in this laboratory covers a broad area of molecular cell biology in mammalian cells. In the past few years, it has taken a particular interest in the use of data-driven modeling of multivariate measurements obtained with quantitative single-cell imaging of large populations of cells to uncover mechanisms by which cells couple and coordinate their activities. Using such an approach, his lab has recently discovered that the cell-to-cell variability of complex activities in identical human cells is largely deterministic, and follows basic predictive principles (Snijder et al., Nature 2009). Further unraveling the molecular and mechanistic basis of these principles is becoming a major interest of his lab.
Specific Contribution to Research in InfectX
Genome-wide RNAi screens twill be performed to identify human proteins involved in the entry of various viruses. The analysis of high-content screens requires the development and implementation of advanced algorithms for image analysis, data analysis, and statistics. This group has been involved in developing such infrastructure, based on widely used open-source software packages, and this is undergoing further development in collaboration with other InfectX participants.
Lab Members Involved in InfectX
Dr. Berend Snijder, Postdoctoral Fellow
Dr. Victoria Green, Postdoctoral Fellow
Yauhen Yakimovich, IT Technician