Prof. Christoph Dehio, Principal Investigator for InfectX- Biozentrum, Basel

 

Prof. Christoph DehioField of research
The research in Christoph Dehio’s group is focused on molecular mechanisms of bacterial pathogenesis. In particular we are studying the role of type IV secretion systems (T4SS) in the evolution and pathogenesis of the related bacterial pathogens Bartonella and Brucella.
 
Specific Contribution to Research in InfectX
The group will perform genome-wide RNAi screens to identify human proteins involved in bacterial entry of Bartonella henselae (integrin-dependent uptake mechanism) and of Brucella abortus (lipid raft‐dependent entry mechanism).
 

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Lab Members Involved in InfectX

Dr Houchaima Ben-Tekaya, Postdoctoral Researcher  Together with Simone Muntwiler, Houchaima has established robust screening assays to perform genome scale RNAi screens for identifying host cell factors required for Bartonella henselae host cell invasion. She is also currently setting up a live cell imaging system to study Brucella intracellular trafficking routes.

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Dr Pauli Rämö, Staff Scientist focusing on developing computational and statistical tools for high-content high-throughput screening

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Dr Simone EicherDr Simone Eicher, Postdoctoral Researcher  Together with Simone Muntwiler, Simone Eicher will perform the genome-wide RNAi screen for factors involved in the infection of HeLa CCL-2 cells with Bartonella henselae.

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Shyan LowShyan Low, Ph.D. Student Together with Raquel Conde, Shyan is performing the genome-wide RNAi screens to identify host cell factors required for Brucella abortus host cell invasion

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Alain CasanovaAlain Casanova, Ph.D. Student Alain will be working with Brucella

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Simone Muntwiler Simone Muntwiler, Technical Associate Simone is responsible for the maintenance of the RNAi screening platform at the Biozentrum. Together with Houchaima Ben-Tekaya, she has also established robust screening assays to perform genome scale RNAi screens to identify host cell factors required for Bartonella henselae host cell invasion.

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Damian Murezzan Damian Murezzan, IT Technician

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Andreas KübacherAndreas Kühbacher, Visiting Researcher from Prof. Pascal Cossart's group at the Insitut Pasteur, Paris. Andreas is performing the genome-wide RNAi screens to identify host cell factors required for Listeria monocytogenes host cell invasion.

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